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10.12.2024
Due to their contact with the human organism and direct intervention in the circulatory system, blood pumps have special requirements in terms of bio 🧫 and haemocompatibility 🩸, in particular the prevention of blood damage ⛓️💥. Blood damage, i.e. damage to the cellular blood components, can occur primarily due to mechanical stresses, e.g. at the bearing points of a pump, but also due to the shear stresses caused by fluid 🧪 and wall friction within the pump.
Blood is pumped in a circuit 🔄 for 6 hours and the damage is measured using free haemoglobin, which is released when the red blood cells are destroyed. This allows an initial statement to be made about the suitability of a pump for use in humans. A final assessment also includes long-term tests and biocompatibility tests 🧫. By taking samples at several points in time ⏱️ during the test, the progression of blood damage can be quantified 📈. The image shows the progression of free haemoglobin for an initial pump variant with high blood damage, a better pump variant with moderate/low blood damage and, as a reference, a blood bag without the influence of a pump.
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